Seattle-Denver Center of Innovation (COIN)

COIN Investigators & Staff

COIN Investigators

Kristina A Crothers, MD

Title: Core Investigator
Professor, University of Washington School of Medicine

Contact: Kristina.Crothers@va.gov

Location: Seattle

University of Washington webpage

See Dr. Crothers' Dimensions profile that includes: publications, grants, datasets, patents and clinical trials

The following images visualize Dr. Crothers' work. The word cloud is drawn from publication titles. The research collaboration map shows research relationships (click the image to enlarge):

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Grants & Funding

Links between Cardiovascular disease, Lung disease, and Obstructive sleep apnea in HIV: Understanding complex patients

Role: Co-PI with Heidi Crane and Joseph Delaney
People with HIV (PWH) face increased morbidity and mortality from non-infectious heart, lung, blood, and sleep (HLBS) disorders. There are many unanswered questions in the current era, including the role of emerging risk factors such as COVID-19, newer antiretroviral therapy (ART) medications, non-traditional risk factors such as social determinants of health, and the increasingly complex interactions of HLBS conditions with each other.
This proposal builds on the large, diverse Center for AIDS Research (CFAR) Network of Integrated Clinical Systems (CNICS) cohort of PWH with comprehensive clinical data, specimens, and socio-behavioral measures to study understudied necessary HLBS conditions such as obstructive sleep apnea, as well as to study evolving risk factors for other conditions such as myocardial infarction, stroke, atrial fibrillation, and venous thromboembolism.
New and timely knowledge about the increasing complexity of HLBS conditions among PWH, including screening, risk factors, and complex interactions of HLBS conditions with each other and other syndemic conditions, will inform clinical decision-making and improve understanding of the mechanisms that increase the frequency of HLBS diseases and risk of poor outcomes in PWH in current clinical care.
Funder: National Heart, Lung, and Blood Institute
NIH website
Publications of note:
— Validity Properties of a Self-reported Modified Frailty Phenotype Among People With HIV in Clinical Care in the United States
— HIV, Aging, and Comorbidities Research in Clinical Cohorts: 3 Lessons Learned Using Examples From the CNICS Cohort
— Insomnia and Risk of Myocardial Infarction Among People with HIV

Chronic Lung Disease and COVID-19: Understanding Severity, Recovery and Rehabilitation Needs (LAUREL Study)

Coronavirus-19 disease (COVID-19) is a global pandemic, and Veterans are at risk of infection and poor outcomes from COVID-19. However, the long-term effects of COVID-19 have yet to be characterized or quantified.
We will determine the outcomes of patients after COVID-19, including their trajectory of health recovery and rehabilitation needs.
We will evaluate risk factors for worse long-term outcomes from COVID-19, such as chronic lung disease and other chronic conditions, to identify individuals at the most significant risk of doing poorly and needing rehabilitation services.
We will assess the feasibility and acceptability of a virtually-delivered, home-based personalized telerehabilitation program for survivors of COVID-19.
Our pilot study will inform future more extensive trials of this novel program to determine if it can improve the function and well-being of individuals after COVID-19.
Funder: Veterans Affairs

VAPSHCS Program Development in Precision Oncology for Screening and Management of Lung Cancer (LPOP)

This program aims to increase delivery and access to precision oncology to improve the early detection and management of lung cancer and patient outcomes.
We will utilize an integrated practice unit (IPU) model to promote high-quality, high-value patient-centered lung cancer care that we will leverage to support an innovative and efficient portfolio of research studies encompassing personalized, precision oncology approaches to lung cancer screening (LCS) and lung cancer treatment.
Funder: Veterans Affairs
NIH website
Publications of note:
— Dexamethasone in hospitalised COVID-19 patients not on intensive respiratory support

Improving the Reach and Effectiveness of Smoking Cessation Services Targeted to Veterans Living with HIV

People living with HIV are a priority group for targeting smoking cessation. Still, standard care cessation treatments reach or benefit only a tiny proportion of these individuals. Interventions are needed to engage smokers who are not yet ready to quit or seek treatment, as well as assist those ready to quit smoking.
This project will compare the effectiveness of an HIV-specific comprehensive wellness intervention designed to appeal broadly to smokers living with HIV to the standard of care services, including referral to the National VA Quitline and SmokefreeVET texting program.
Participants in both study arms will have access to pharmacotherapy available through their Veterans Affairs (VA) healthcare providers.
Funder: National Cancer Institute
NIH website
Publications of note:
— The United States National Cancer Institute’s Coordinated Research Effort on Tobacco Use as a Major Cause of Morbidity and Mortality among People with HIV
Design and Methods of a Randomized Trial Testing the Novel Wellness Intervention for Smokers Living with HIV (WISH)
— COVID-19 Challenges Confronted by Smoking Cessation Clinical Trials for People Living With HIV: The Experience of Grantees of the US National Cancer Institute
— Receipt and Predictors of Smoking Cessation Pharmacotherapy among Veterans With and Without HIV

AdvanCing High quality COPD care for people with immune dysfunction by implementing Evidence-based management through proactive E-consults (ACHIEVE)

Role: Co-PI with Christian Helfrich; David Au is PI
Chronic obstructive pulmonary disease (COPD) is common and associated with morbidity and mortality in HIV-infected patients. However, COPD is often underdiagnosed, and care is suboptimal.
We propose to test an intervention to proactively support primary care providers of HIV-infected patients and make evidence-based recommendations to improve the care and health of their patients with COPD.
Funder: National Heart, Lung, and Blood Institute
NIH website
Publications of note:
— A cross-sectional analysis of diagnosis and management of chronic obstructive pulmonary disease in people living with HIV
— Receipt and Predictors of Smoking Cessation Pharmacotherapy among Veterans With and Without HIV
— ImPlementation REsearCh to DEvelop Interventions for People Living with HIV (The PRECluDE Consortium): Combatting Chronic Disease Comorbidities in HIV Populations through Implementation Research
— Community‐Acquired Pneumonia and Risk of Cardiovascular Events in People Living With HIV

EPIC 3 (Epidemiology, Immunology, and Clinical Characteristics of Covid-19 within the VA)

Role: Co-PI
EPIC3 is a nationwide study to determine the natural history, clinical outcomes, and development of immunity in COVID-19 Veteran patients while also creating a biorepository of specimens for future study.
Funder: National Heart, Lung, and Blood Institute
NIH website

Characterizing chronic lung disease in youth living with HIV: quantitative chest CT analyses

As increasing numbers of children living with HIV survive to adolescence and early adulthood, chronic lung disease is emerging as an important but poorly understood complication among youth living with HIV.
This project determines the clinical characteristics associated with lung abnormalities defined by quantitative CT metrics in youth living with HIV. It determines whether these quantitative CT metrics can identify chronic lung disease subtypes related to lung function growth trajectories.
Findings from this study will fill gaps in knowledge of chronic lung disease subtypes in youth living with HIV, provide a better understanding of mechanisms earlier in the cascade of impairment caused by chronic lung disease in these youth, and offer an opportunity for early subtype-targeted interventions to mitigate disease progression.
Funder: Veterans Administration

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Recent Publications

2024

Triplette M, Kross EK, Snidarich M, Shahrir S, Hippe DS, Crothers K. An alternating-intervention pilot trial on the impact of an informational handout on patient-reported outcomes and follow-up after lung cancer screening. PLoS One. 2024 Apr 10;19(4):e0300352. doi: 10.1371/journal.pone.0300352. PMCID: PMC11006146.
PMID: 38598511.

Crothers K, Adams SV, Turner AP, Batten L, Nikzad R, Kundzins JR, Fan VS. COVID-19 Severity and Mortality in Veterans with Chronic Lung Disease. Ann Am Thorac Soc. 2024 Mar 26. doi: 10.1513/AnnalsATS.202311-974OC. Epub ahead of print.
PMID: 38530061.
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Abelman RA, Fitzpatrick J, Byanova KL, Zawedde J, Sanyu I, Byanyima P, Musisi E, Hsieh J, Zhang M, Branchini J, Sessolo A, Hunt PW, Lalitha R, Davis JL, Crothers K, Worodria W, Huang L. Sex and HIV Differences in Preserved Ratio Impaired Spirometry (PRISm) Among Ugandans Postpneumonia. Open Forum Infect Dis. 2024 Jan 22;11(3):ofae033. doi: 10.1093/ofid/ofae033. PMCID: PMC10919919.
PMID: 38456193.
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Hayes S, Duan KI, Wai TH, Picazo F, Donovan LM, Spece LJ, Plumley R, Slatore CG, Thakur N, Crothers K, Au DH, Feemster LC. Association Between Neighborhood Socioeconomic Disadvantage and Chronic Obstructive Pulmonary Disease Prevalence Among U.S. Veterans. Ann Am Thorac Soc. 2024 Jan 22. doi: 10.1513/AnnalsATS.202308-668RL. Epub ahead of print.
PMID: 38252425.
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2023

Crane HM, Nance RM, Ruderman SA, Haidar L, Tenforde MW, Heckbert SR, Budoff MJ, Hahn AW, Drumright LN, Ma J, Mixson LS, Lober WB, Barnes GS, McReynolds J, Attia EF, Peter I, Moges T, Bamford L, Cachay E, Mathews WC, Christopolous K, Hunt PW, Napravnik S, Keruly J, Moore RD, Burkholder G, Willig AL, Lindstrom S, Whitney BM, Saag MS, Kitahata MM, Crothers KA, Delaney JA. Venous thromboembolism among people with HIV: Design, implementation, and findings of a centralized adjudication system in clinical care sites across the United States. J Acquir Immune Defic Syndr. 2023 Nov 21. doi: 10.1097/QAI.0000000000003339. Epub ahead of print.
PMID: 37988634.
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Duan KI, Donovan LM, Spece LJ, Wong ES, Feemster LC, Bryant AD, Plumley R, Crothers K, Au DH. Inhaler Formulary Change in COPD and the Association with Exacerbations, Health Care Utilization, and Costs. Chronic Obstr Pulm Dis. 2023 Nov 6. doi: 10.15326/jcopdf.2023.0425. Epub ahead of print.
PMID: 37931593.
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Donovan LM, Wai T, Spece LJ, Duan KI, Griffith MF, Leonhard A, Plumley R, Hayes SA, Picazo F, Crothers K, Kapur VK, Palen BN, Au DH, Feemster LC. Sleep Testing and Mortality in a Propensity-matched Cohort of Patients with Chronic Obstructive Pulmonary Disease. Ann Am Thorac Soc. 2023 Aug 14. doi: 10.1513/AnnalsATS.202303-275OC. Epub ahead of print. PMID: 37579136.
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Ross JM, Sugimoto JD, Timmons A, Adams J, Deardoff K, Korpak A, Liu C, Moore K, Wilson D, Bedimo R, Chang KM, Cho K, Crothers K, Garshick E, Gaziano JM, Holodniy M, Hunt CM, Isaacs SN, Le E, Jones BE, Shah JA, Smith NL, Lee JS; EPIC Investigators. Early Outcomes of SARS-CoV-2 Infection in a Multisite Prospective Cohort of Inpatient Veterans. Open Forum Infect Dis. 2023 Jun 27;10(7):ofad330. doi: 10.1093/ofid/ofad330. PMCID: PMC10358428.
PMID: 37484899
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Ives J, Bagchi S, Soo S, Barrow C, Akgün KM, Erlandson KM, Goetz M, Griffith M, Gross R, Hulgan T, Moanna A, Soo Hoo GW, Weintrob A, Wongtrakool C, Adams SV, Sayre G, Helfrich CD, Au DH, Crothers K. Design and methods of a randomized trial testing advancing care for COPD in people living with HIV by implementing evidence-based management through proactive E-consults (ACHIEVE). Contemp Clin Trials. 2023 Jul 20:107303. doi: 10.1016/j.cct.2023.107303. Epub ahead of print.
PMID: 37481201
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Byanova KL, Fitzpatrick J, Jan AK, McGing M, Hartman-Filson M, Farr CK, Zhang M, Gardner K, Branchini J, Kerruish R, Bhide S, Bates A, Hsieh J, Abelman R, Hunt PW, Wang RJ, Crothers KA, Huang L. Isolated abnormal diffusing capacity for carbon monoxide (iso↓DLco) is associated with increased respiratory symptom burden in people with HIV infection. PLoS One. 2023 Jul 18;18(7):e0288803. doi: 10.1371/journal.pone.0288803. PMCID: PMC10353811.
PMID: 37463173
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Konstantinidis I, Crothers K, Kunisaki KM, Drummond MB, Benfield T, Zar HJ, Huang L, Morris A. HIV-associated lung disease. Nat Rev Dis Primers. 2023 Jul 27;9(1):39. doi: 10.1038/s41572-023-00450-5.
PMID: 37500684
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Sigel K, Silverberg MJ, Crothers K, Park L, Lishchenko I, Han X, Leyden W, Kale M, Stone K, Sigel C, Wisnivesky J, Kong CY. Comparison of Stage I Non-Small-Cell Lung Cancer Treatments for Patients Living With HIV: A Simulation Study. Clin Lung Cancer. 2023 Jun 14:S1525-7304(23)00122-5. doi: 10.1016/j.cllc.2023.06.004. Epub ahead of print.
PMID: 37407294
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Abelman RA, Fitzpatrick J, Zawedde J, Sanyu I, Byanyima P, Kaswabuli S, Musisi E, Hsieh J, Gardner K, Zhang M, Byanova KL, Sessolo A, Hunt PW, Lalitha R, Davis JL, Crothers K, Worodria W, Huang L. Sex modifies the risk of HIV-associated obstructive lung disease in Ugandans post-pneumonia. AIDS. 2023 Jun 20. doi: 10.1097/QAD.0000000000003626. Epub ahead of print.
PMID: 37352494
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Bernstein E, DeRycke EC, Han L, Farmer MM, Bastian LA, Bean-Mayberry B, Bade B, Brandt C, Crothers K, Skanderson M, Ruser C, Spelman J, Bazan IS, Justice AC, Rentsch CT, Akgün KM. Racial, Ethnic, and Rural Disparities in US Veteran COVID-19 Vaccine Rates. AJPM Focus. 2023 Mar 24:100094. doi: 10.1016/j.focus.2023.100094. Epub ahead of print. PMCID: PMC10038675.
PMID: 37362395
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Abdo M, Kunisaki KM, Morris A, Stosor V, Chang D, D'Souza G, Crothers K, Abdel-Maksoud M, DiGuiseppi C, Brown TT, Erlandson KM, MaWhinney S. Pulmonary Function and Quality of Life in Aging Men with and without HIV from the Multicenter AIDS Cohort Study (MACS). AIDS Res Hum Retroviruses. 2023 Jun 5. doi: 10.1089/AID.2023.0001. Epub ahead of print.
PMID: 37276144
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McGinnis KA, Skanderson M, Justice AC, Tindle HA, Akgün KM, Wrona A, Freiberg MS, Goetz MB, Rodriguez-Barradas MC, Brown ST, Crothers KA. Using the biomarker cotinine and survey self-report to validate smoking data from United States Veterans Health Administration electronic health records. JAMIA Open. 2022 May 26;5(2):ooac040. doi: 10.1093/jamiaopen/ooac040. PMCID: PMC9154288.
PMID: 37252267
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Núñez ER, Slatore CG, Tanner NT, Melzer AC, Crothers K, Lewis JA, Fabbrini A, Brown JK, Wiener RS. National Survey of Lung Cancer Screening Practices in Veterans Health Administration Facilities. Am J Prev Med. 2023 May 9:S0749-3797(23)00207-6. doi: 10.1016/j.amepre.2023.05.005. Epub ahead of print.
PMID: 37169315
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Triplette M, Brown MC, Snidarich M, Budak JZ, Giustini N, Murphy N, Romine PE, Weiner BJ, Crothers K. Lung Cancer Screening in People with HIV: A Mixed-Methods Study of Patient and Provider Perspectives. Am J Prev Med. 2023 May 3:S0749-3797(23)00204-0. doi: 10.1016/j.amepre.2023.05.001. Epub ahead of print.
PMID: 37146840
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Ahmed A, Hippe DS, Snidarich M, Crothers K, Triplette M. Delays in Recommended Follow-up after Positive Findings in Lung Cancer Screening . Ann Am Thorac Soc. 2023 Mar 27. doi: 10.1513/AnnalsATS.202210-891OC. Epub ahead of print.
PMID: 36973008
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Temu TM, Polyak SJ, Wanjalla CN, Mandela NA, Dabee S, Mogaka JN, Masyuko S, Longernecker C, Shakil S, Chohan B, Page ST, Lacourse SM, Gitura B, Crothers K, Oyugi J, Jaspan H, Farquhar C, Zifodya JS. Latent tuberculosis is associated with heightened levels of pro-and anti-inflammatory cytokines among Kenyan men and women living with HIV on long-term antiretroviral therapy. AIDS. 2023 Mar 6. doi: 10.1097/QAD.0000000000003523. Epub ahead of print.
PMID: 36928263
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Cheng GS, Crothers K, Aliberti S, Bergeron A, Boeckh M, Chien JW, Cilloniz C, Cohen K, Dean N, Dela Cruz CS, Dickson RP, Greninger AL, Hage CA, Hohl TM, Holland SM, Jones BE, Keane J, Metersky M, Miller R, Puel A, Ramirez J, Restrepo MI, Sheshadri A, Staitieh B, Tarrand J, Winthrop KL, Wunderink RG, Evans SE. Immunocompromised Host Pneumonia: Definitions and Diagnostic Criteria: An Official American Thoracic Society Workshop Report. Ann Am Thorac Soc. 2023 Mar;20(3):341-353. doi: 10.1513/AnnalsATS.202212-1019ST.
PMID: 36856712
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Shahrir S, Crothers K, McGinnis KA, Chan KCG, Baeten JM, Wilson SM, Butt AA, Pisani MA, Baldassarri SR, Justice A, Williams EC. Receipt of Smoking Cessation Medications Among People With and Without Human Immunodeficiency Virus in the Veterans Aging Cohort Study (2003-2018). Open Forum Infect Dis. 2023 Feb 20;10(3):ofad089. doi: 10.1093/ofid/ofad089. PMCID: PMC10034589.
PMID: 36968969
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Akgün KM, Krishnan S, Tate J, Bryant K, Pisani MA, Lo Re V 3rd, Rentsch CT, Crothers K, Gordon KS, Justice AC; VACS project team. Delirium among people aging with and without HIV: Role of alcohol and Neurocognitively active medications. J Am Geriatr Soc. 2023 Feb 14. doi: 10.1111/jgs.18265. Epub ahead of print.
PMID: 36786300
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Gundle K, Hooker ER, Golden SE, Shull S, Crothers K, Melzer AC, Slatore CG. Use of Veterans Health Administration Structured Data to Identify Patients Eligible for Lung Cancer Screening. Mil Med. 2023 Jan 31:usad017. doi: 10.1093/milmed/usad017. Epub ahead of print.
PMID: 36722178
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2022

Crothers K, Nance RM, Whitney BM, Harding BN, Heckbert SR, Budoff MJ, Mathews WC, Bamford L, Cachay ER, Eron JJ, Napravnik S, Moore RD, Keruly JC, Willig A, Burkholder G, Feinstein MJ, Saag MS, Kitahata MM, Crane HM, Delaney JAC; for Cnics. Copd And The Risk For Myocardial Infarction By Type In People With Hiv. AIDS. 2022 Dec 26. doi: 10.1097/QAD.0000000000003465. Epub ahead of print.
PMID: 36728918
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Burns KEA, Moss M, Lorens E, Jose EKA, Martin CM, Viglianti EM, Fox-Robichaud A, Mathews KS, Akgun K, Jain S, Gershengorn H, Mehta S, Han JE, Martin GS, Liebler JM, Stapleton RD, Trachuk P, Vranas KC, Chua A, Herridge MS, Tsang JLY, Biehl M, Burnham EL, Chen JT, Attia EF, Mohamed A, Harkins MS, Soriano SM, Maddux A, West JC, Badke AR, Bagshaw SM, Binnie A, Carlos WG, Çoruh B, Crothers K, D'Aragon F, Denson JL, Drover JW, Eschun G, Geagea A, Griesdale D, Hadler R, Hancock J, Hasmatali J, Kaul B, Kerlin MP, Kohn R, Kutsogiannis DJ, Matson SM, Morris PE, Paunovic B, Peltan ID, Piquette D, Pirzadeh M, Pulchan K, Schnapp LM, Sessler CN, Smith H, Sy E, Thirugnanam S, McDonald RK, McPherson KA, Kraft M, Spiegel M, Dodek PM; Diversity-Related Research Committee of the Women in Critical Care (WICC) Interest Group of the American Thoracic Society. Wellness and Coping of Physicians Who Worked in ICUs During the Pandemic: A Multicenter Cross-Sectional North American Survey. Crit Care Med. 2022 Oct 27. doi: 10.1097/CCM.0000000000005674. Epub ahead of print.
PMID: 36300945
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Gordon KS, Crothers K, Butt AA, Edelman EJ, Gibert C, Pisani MM, Rodriguez-Barradas M, Wyatt C, Justice AC, Akgün KM. Polypharmacy and medical intensive care unit (MICU) admission and 10-year all-cause mortality risk among hospitalized patients with and without HIV. PLoS One. 2022 Oct 27;17(10):e0276769. doi: 10.1371/journal.pone.0276769. PMCID: PMC9612570.
PMID: 36302039
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Abdo M, Kunisaki KM, Morris A, Stosor V, Chang D, D'Souza G, Crothers K, Abdel-Maksoud M, DiGuiseppi C, Brown TT, MaWhinney S, Erlandson KM. Pulmonary and Physical Function Limitations in Aging Men with and without HIV from the Multicenter AIDS Cohort Study (MACS). Ann Epidemiol. 2022 Oct 13:S1047-2797(22)00248-4. doi: 10.1016/j.annepidem.2022.10.005. Epub ahead of print.
PMID: 36244514
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Crothers K, Shahrir S, Kross EK, Kava CM, Cole A, Wenger D, Triplette M. Patient and clinician recommendations to improve communication and understanding of lung cancer screening results. Chest. 2022 Oct 6:S0012-3692(22)03908-3. doi: 10.1016/j.chest.2022.09.038. Epub ahead of print.
PMID: 36209835
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Bade B, Gwin M, Triplette M, Wiener RS, Crothers K. Comorbidity and life expectancy in shared decision making for lung cancer screening. Semin Oncol. 2022 Jul 21:S0093-7754(22)00057-4. doi: 10.1053/j.seminoncol.2022.07.003. Epub ahead of print.
PMID: 35940959
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Yee N, Mann BA, Crothers KA, Albert TJ. 52-year-old man • hematemesis • history of cirrhosis • persistent fevers • Dx? J Fam Pract. 2022 Apr;71(3):E17-E19. doi: 10.12788/jfp.0385.
PMID: 35561241
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Zifodya JS, Crothers K. Tuberculosis, Chronic Obstructive Lung Disease, and Lung Cancer: The Holey Upper Lobe Trinity? Ann Am Thorac Soc. 2022 Apr;19(4):540-542. doi: 10.1513/AnnalsATS.202201-009ED.
PMID: 35363131
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Luu B, Ruderman S, Nance R, Delaney JAC, Ma J, Hahn A, Heckbert SR, Budoff MJ, Crothers K, Mathews WC, Christopolous K, Hunt PW, Eron J, Moore R, Keruly J, Lober WB, Burkholder GA, Willig A, Chander G, McCaul ME, Cropsey K, O'Cleirigh C, Peter I, Feinstein M, Tsui JI, Lindstroem S, Saag M, Kitahata MM, Crane HM, Drumright LN, Whitney BM. Tobacco smoking and binge alcohol use are associated with incident venous thromboembolism in an HIV cohort. HIV Med. 2022 Mar 28. doi: 10.1111/hiv.13309. Epub ahead of print.
PMID: 35343038
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Holman A, Kross E, Crothers K, Cole A, Wernli K, Triplette M. Patient Perspectives on Longitudinal Adherence to Lung Cancer Screening. Chest. 2022 Feb 8:S0012-3692(22)00223-9. doi: 10.1016/j.chest.2022.01.054. Epub ahead of print.
PMID: 35149081
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2021

Crothers K, DeFaccio R, Tate J, Alba PR, Goetz MB, Jones B, King JT Jr, Marconi V, Ohl ME, Rentsch CT, Rodriguez-Barradas MC, Shahrir S, Justice AC, Akgün KM; Veterans Aging Cohort Study Clinical COVID-19 Working Group. Dexamethasone in hospitalised coronavirus-19 patients not on intensive respiratory support. Eur Respir J. 2021 Nov 25:2102532. doi: 10.1183/13993003.02532-2021. Epub ahead of print.
PMID: 34824060

Crothers K, Schnapp L. World AIDS Day: 40 Years of an Evolving Pulmonary Landscape. Am J Physiol Lung Cell Mol Physiol. 2021 Nov 10. doi: 10.1152/ajplung.00457.2021. Epub ahead of print.
PMID: 34755570

McClure JB, Catz SL, Chalal C, Ciuffetelli R, Coggeshall S, DeFaccio RJ, Fleehart S, Heffner JL, Thompson E, Williams EC, Crothers K. Design and methods of a randomized trial testing the novel Wellness Intervention for Smokers Living with HIV (WISH). Contemp Clin Trials. 2021 Nov;110:106486. doi: 10.1016/j.cct.2021.106486. Epub 2021 Oct 27.
PMID: 34776121

Triplette M, Wenger DS, Shahrir S, Kross EK, Kava C, Phipps A, Hawes SE, Cole A, Snidarich M, Crothers K. Patient Identification of Lung Cancer Screening Follow-up Recommendations and the Association with Adherence. Ann Am Thorac Soc. 2021 Nov 2. doi: 10.1513/AnnalsATS.202107-887OC. Epub ahead of print.
PMID: 34727513

Zifodya JS, Triplette M, Shahrir S, Attia EF, Akgun KM, Soo Hoo GW, Rodriguez-Barradas MC, Wongtrakool C, Huang L, Crothers K. A cross-sectional analysis of diagnosis and management of chronic obstructive pulmonary disease in people living with HIV: Opportunities for improvement. Medicine (Baltimore). 2021 Sep 17;100(37):e27124. doi: 10.1097/MD.0000000000027124. PMCID: PMC8448060.
PMID: 34664836

Leapman MS, Stone K, Wadia R, Park LS, Gibert CL, Goetz MB, Bedimo R, Rodriguez-Barradas M, Shebl F, Justice AC, Brown ST, Crothers K, Sigel KM. Prostate Cancer Screening and Incidence Among Aging Persons Living with HIV. J Urol. 2021 Sep 24:101097JU0000000000002249. doi: 10.1097/JU.0000000000002249. Epub ahead of print.
PMID: 34555924

Zifodya JS, Triplette M, Shahrir S, Attia EF, Akgun KM, Soo Hoo GW, Rodriguez-Barradas MC, Wongtrakool C, Huang L, Crothers K. A cross-sectional analysis of diagnosis and management of chronic obstructive pulmonary disease in people living with HIV: Opportunities for improvement. Medicine (Baltimore). 2021 Sep 17;100(37):e27124. doi: 10.1097/MD.0000000000027124. PMCID: PMC8448060

Makinson A, Park LS, Stone K, Tate J, Rodriguez-Barradas MC, Brown ST, Wadia R, Crothers K, Bedimo R, Goetz MB, Shebl F, Reynes J, Moing VL, Sigel KM. Risks of Opportunistic Infections in People With Human Immunodeficiency Virus With Cancers Treated With Chemotherapy. Open Forum Infect Dis. 2021 Jul 19;8(8):ofab389. doi: 10.1093/ofid/ofab389. PMCID: PMC8391784.
PMID: 34458394

Jan AK, Moore JV, Wang RJ, Mcging M, Farr CK, Moisi D, Hartman-Filson M, Kerruish R, Jeon D, Lewis E, Crothers K, Lederman MM, Hunt PW, Huang L. Markers of inflammation and immune activation are associated with lung function in a multi-center cohort of persons with HIV. AIDS. 2021 Jun 1;35(7):1031-1040. doi: 10.1097/QAD.0000000000002846. PMCID: PMC8102352.
PMID: 33635847

Singhvi DG, Nouraie M, Kessinger C, McMahon DK, Weinman R, Crothers K, Huang L, Bon J, Morris A, Merlin J. Brief Report: Association Between Pain, Pulmonary Function, and Respiratory Symptoms in People With HIV. J Acquir Immune Defic Syndr. 2021 Aug 15;87(5):1161-1166. doi: 10.1097/QAI.0000000000002696. PMCID: PMC8263479.
PMID: 33871410

Duncan MS, Alcorn CW, Freiberg MS, So-Armah K, Patterson OV, DuVall SL, Crothers KA, Re VL 3rd, Butt AA, Lim JK, Kim JW, Tindle HA, Justice AC, Brittain EL. Association between HIV and incident pulmonary hypertension in US Veterans: a retrospective cohort study. Lancet Healthy Longev. 2021 Jul;2(7):e417-e425. doi: 10.1016/s2666-7568(21)00116-1. Epub 2021 Jun 16. PMCID: PMC8294078.
PMID: 34296203

Akgün KM, Krishnan S, Butt AA, Gibert CL, Graber CJ, Huang L, Pisani MA, Rodriguez-Barradas MC, Hoo GWS, Justice AC, Crothers K, Tate JP. HIV-infected medical ICU (MICU) survivors without CD4 cell recovery are at increased risk for poor outcomes regardless of viral suppression in a national cohort. AIDS. 2021 Jul 8. doi: 10.1097/QAD.0000000000003019. Epub ahead of print.
PMID: 34261095

Ohl ME, Miller DR, Lund BC, Kobayashi T, Richardson Miell K, Beck BF, Alexander B, Crothers K, Vaughan Sarrazin MS. Association of Remdesivir Treatment With Survival and Length of Hospital Stay Among US Veterans Hospitalized With COVID-19. JAMA Netw Open. 2021 Jul 1;4(7):e2114741. doi: 10.1001/jamanetworkopen.2021.14741. PMCID: PMC8283561.
PMID: 34264329

Zifodya JS, Temu TM, Masyuko SJ, Nyale G, Kinuthia J, Page ST, LaCourse SM, Kolls J, Farquhar C, Crothers K. HIV, Pulmonary Infections, and Risk of Chronic Lung Disease among Kenyan Adults. Ann Am Thorac Soc. 2021 Jul 8. doi: 10.1513/AnnalsATS.202103-251RL. Epub ahead of print.
PMID: 34237231

O'Hare AM, Berry K, Fan VS, Crothers K, Eastment MC, Dominitz JA, Shah JA, Green P, Locke E, Ioannou GN. Age differences in the association of comorbid burden with adverse outcomes in SARS-CoV-2. BMC Geriatr. 2021 Jul 6;21(1):415. doi: 10.1186/s12877-021-02340-5. PMCID: PMC8258273.
PMID: 34229623.

Dela Cruz CS, Evans SE, Restrepo MI, Dean N, Torres A, Amara-Elori I, Awasthi S, Caler E, Cao B, Chalmers JD, Chastre J, Cohen TS, Cohen AH, Crothers K, Di YP, Egan ME, Feldman C, Gautam S, Halstead ES, Herold S, Jones BE, Luna C, Niederman MS, Mendez R, Menendez R, Mizgerd JP, Nusrat R, Ramirez J, Shindo Y, Waterer G, Yeligar SM, Wunderink RG. Understanding the Host in the Management of Pneumonia. An Official American Thoracic Society Workshop Report. Ann Am Thorac Soc. 2021 Jul;18(7):1087-1097. doi: 10.1513/AnnalsATS.202102-209ST.
PMID: 34242148

Chichetto NE, Kundu S, Freiberg MS, Koethe JR, Butt AA, Crystal S, So-Armah KA, Cook RL, Braithwaite RS, Justice AC, Fiellin DA, Khan M, Bryant KJ, Gaither JR, Barve SS, Crothers K, Bedimo RJ, Warner A, Tindle HA; Veterans Aging Cohort Study. Association of Syndemic Unhealthy Alcohol Use, Smoking, and Depressive Symptoms on Incident Cardiovascular Disease among Veterans With and Without HIV-Infection. AIDS Behav. 2021 Jun 8. doi: 10.1007/s10461-021-03327-4. Epub ahead of print.
PMID: 34101074

Ioannou GN, O'Hare AM, Berry K, Fan VS, Crothers K, Eastment MC, Locke E, Green P, Shah JA, Dominitz JA. Trends over time in the risk of adverse outcomes among patients with SARS-CoV-2 infection. Clin Infect Dis. 2021 May 11:ciab419. doi: 10.1093/cid/ciab419. Epub ahead of print.
PMID: 33973000

Evans SE, Jennerich AL, Azar MM, Cao B, Crothers K, Dickson RP, Herold S, Jain S, Madhavan A, Metersky ML, Myers LC, Oren E, Restrepo MI, Semret M, Sheshadri A, Wunderink RG, Dela Cruz CS. Nucleic Acid-based Testing for Noninfluenza Viral Pathogens in Adults with Suspected Community-acquired Pneumonia. An Official American Thoracic Society Clinical Practice Guideline. Am J Respir Crit Care Med. 2021 May 1;203(9):1070-1087. doi: 10.1164/rccm.202102-0498ST.
PMID: 33929301

Triplette M, Crothers K. Reply: Early Adherence to Lung Cancer Screening. Ann Am Thorac Soc. 2021 Apr;18(4):734. doi: 10.1513/AnnalsATS.202101-061LE. PMCID: PMC8009006.
PMID: 33507854

Shen J, Crothers K, Kross EK, Petersen K, Melzer AC, Triplette M. Provision of Smoking Cessation Resources in the Context of In-Person Shared Decision-Making for Lung Cancer Screening. Chest. 2021 Aug;160(2):765-775. doi: 10.1016/j.chest.2021.03.016. Epub 2021 Mar 18.
PMID: 33745990

Sigel K, Kong CY, Rehmani S, Bates S, Gould M, Stone K, Kale M, Park YH, Crothers K, Bhora F, Wisnivesky J. Optimal treatment strategies for stage I non-small cell lung cancer in veterans with pulmonary and cardiac comorbidities. PLoS One. 2021 Mar 18;16(3):e0248067. doi: 10.1371/journal.pone.0248067. PMCID: PMC7971489.
PMID: 33735217

Schnoll R, Bernstein SL, Kaufman A, Gross R, Catz SL, Cioe PA, Hitsman B, Marhefka SL, Pacek LR, Vidrine DJ, Vilardaga R, Edelman EJ, McClure JB, Ashare R, Lockhart E, Crothers K. COVID-19 Challenges Confronted by Smoking Cessation Clinical Trials for People Living with HIV: The Experience of Grantees of the United States National Cancer Institute. Nicotine Tob Res. 2021 Feb 28:ntab035. doi: 10.1093/ntr/ntab035. Epub ahead of print. PMCID: PMC7989188.
PMID: 33657227

Ehteshami-Afshar S, Crothers K, Rodwin B, Bade B, Brandt C, Akgün KM. Does pulmonary subspecialty referral from primary care affect the adherence to vaccination recommendations in COPD patients? Respir Res. 2021 Feb 12;22(1):50. doi: 10.1186/s12931-021-01639-6. Erratum in: Respir Res. 2021 Mar 15;22(1):82. PMCID: PMC7880521.
PMID: 33579277

Bedimo RJ, Park LS, Shebl FM, Sigel K, Rentsch CT, Crothers K, Rodriguez-Barradas MC, Goetz MB, Butt AA, Brown ST, Gibert C, Justice AC, Tate JP. Statin exposure and risk of cancer in people with and without HIV infection. AIDS. 2021 Feb 2;35(2):325-334. doi: 10.1097/QAD.0000000000002748. PMCID: PMC7775280.
PMID: 33181533

2020

Zifodya JS, Duncan MS, So-Armah KA, Attia EF, Akgün KM, Rodriguez-Barradas MC, Marconi VC, Budoff MJ, Bedimo RJ, Alcorn CW, Soo Hoo GW, Butt AA, Kim JW, Sico JJ, Tindle HA, Huang L, Tate JP, Justice AC, Freiberg MS, Crothers K. Community-Acquired Pneumonia and Risk of Cardiovascular Events in People Living With HIV. J Am Heart Assoc. 2020 Dec;9(23):e017645. doi: 10.1161/JAHA.120.017645. Epub 2020 Nov 23. PMCID: PMC7763776.
PMID: 33222591

Eastment MC, Berry K, Locke E, Green P, O'Hare A, Crothers K, Dominitz J, Fan VS, Shah JA, Ioannou GN. Body mass index (BMI) and outcomes of SARS-CoV-2 among US veterans. Obesity (Silver Spring). 2020 Dec 18. doi: 10.1002/oby.23111. Epub ahead of print.
PMID: 33336934

Ioannou GN, Liang PS, Locke E, Green P, Berry K, O'Hare AM, Shah JA, Crothers K, Eastment MC, Fan VS, Dominitz JA. Cirrhosis and SARS-CoV-2 infection in US Veterans: risk of infection, hospitalization, ventilation and mortality. Hepatology. 2020 Nov 21. doi: 10.1002/hep.31649. Epub ahead of print. PMID: 33219546

Fan VS, Dominitz JA, Eastment MC, Locke E, Green P, Berry K, O'Hare AM, Shah JA, Crothers K, Ioannou GN. Risk Factors for testing positive for SARS-CoV-2 in a national US healthcare system. Clin Infect Dis. 2020 Oct 27:ciaa1624. doi: 10.1093/cid/ciaa1624. Epub ahead of print. PMCID: PMC7665412. PMID: 33105485

Wenger DS, Triplette M, Shahrir S, Akgun KM, Wongtrakool C, Brown ST, Kim JW, Soo Hoo GW, Rodriguez-Barradas MC, Huang L, Feemster LC, Zifodya J, Crothers K. Associations of marijuana with markers of chronic lung disease in people living with HIV. HIV Med. 2020 Oct 6. doi: 10.1111/hiv.12966. Epub ahead of print. PMID: 33022830

Zola CE, Duncan MS, So-Armah K, Crothers KA, Butt AA, Gibert CL, Kim JWW, Lim JK, Re VL 3rd, Tindle HA, Freiberg MS, Brittain EL. HIV- and HCV-specific markers and echocardiographic pulmonary artery systolic pressure among United States veterans. Sci Rep. 2020 Oct 30;10(1):18729. doi: 10.1038/s41598-020-75290-4. PMCID: PMC7599329. PMID: 33127959

Bai C, Chotirmall SH, Rello J, Alba GA, Ginns LC, Krishnan JA, Rogers R, Bendstrup E, Burgel PR, Chalmers JD, Chua A, Crothers KA, Duggal A, Kim YW, Laffey JG, Luna CM, Niederman MS, Raghu G, Ramirez JA, Riera J, Roca O, Tamae-Kakazu M, Torres A, Watkins RR, Barrecheguren M, Belliato M, Chami HA, Chen R, Cortes-Puentes GA, Delacruz C, Hayes MM, Heunks LMA, Holets SR, Hough CL, Jagpal S, Jeon K, Johkoh T, Lee MM, Liebler J, McElvaney GN, Moskowitz A, Oeckler RA, Ojanguren I, O'Regan A, Pletz MW, Rhee CK, Schultz MJ, Storti E, Strange C, Thomson CC, Torriani FJ, Wang X, Wuyts W, Xu T, Yang D, Zhang Z, Wilson KC. Updated guidance on the management of COVID-19: from an American Thoracic Society/European Respiratory Society coordinated International Task Force (29 July 2020). Eur Respir Rev. 2020 Oct 5;29(157):200287. doi: 10.1183/16000617.0287-2020. PMCID: PMC7537943. PMID: 33020069

Ramirez JA, Musher DM, Evans SE, Dela Cruz C, Crothers KA, Hage CA, Aliberti S, Anzueto A, Arancibia F, Arnold F, Azoulay E, Blasi F, Bordon J, Burdette S, Cao B, Cavallazzi R, Chalmers J, Charles P, Chastre J, Claessens YE, Dean N, Duval X, Fartoukh M, Feldman C, File T, Froes F, Furmanek S, Gnoni M, Lopardo G, Luna C, Maruyama T, Menendez R, Metersky M, Mildvan D, Mortensen E, Niederman MS, Pletz M, Rello J, Restrepo MI, Shindo Y, Torres A, Waterer G, Webb B, Welte T, Witzenrath M, Wunderink R. Treatment of Community-Acquired Pneumonia in Immunocompromised Adults: A Consensus Statement Regarding Initial Strategies. Chest. 2020 Nov;158(5):1896-1911. doi: 10.1016/j.chest.2020.05.598. Epub 2020 Jun 16. PMCID: PMC7297164. PMID: 32561442

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Awards, Honors

2021 VA Hospital & Specialty Medicine, Practitioner Lead in Quality & Safety (PLQS) Award for the VISN 20 Centralized Lung Cancer Screening Project, Fiscal Year 2021

2017 University of Washington Department of Medicine Mentoring Award for Physician-Scientists

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