COIN Investigators & Staff - Seattle-Denver Center of Innovation (COIN)
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COIN Investigators & Staff

COIN Investigators

 

Sridharan Raghavan, MD, PhD
Title: Attending Physician, Medicine Service
Assistant Professor, University of Colorado Anschutz Medical Campus
Contact: Sridharan.Raghavan@va.gov
Location: Denver
University of Colorado webpage
See Dr. Raghavan's Dimensions profile that includes: publications, grants, datasets, patents and clinical trials
My research focuses on precision medicine applied to the prevention and treatment of obesity, diabetes, and their complications, particularly cardiovascular disease. I am interested in how electronic health record data and genetic data can guide individualized tailoring of preventive interventions to reduce obesity, diabetes, and cardiovascular disease as well as optimal personalized pharmacotherapy.
Cardiometabolic diseases – obesity, diabetes, cardiovascular disease – affect large proportions of our population and are particularly prevalent in Veterans. Despite impacting a diverse population, treatment recommendations largely focus on one-size-fits-all approaches to diabetes prevention and care. I’m hopeful that we can add evidence to support a more individualized approach to treating Veterans affected by any of these conditions.
The potential impact of our work will be to update how clinicians estimate risk of diabetes and diabetes complications for Veterans, how we use that estimated risk to tailor treatment, and how we use clinical and genetic data to select treatments for diabetes prevention and care that maximize benefit and minimize harm.

The following images visualize Dr. Raghavan's work. The word cloud is drawn from publication titles. The research collaboration map shows research relationships (click the image to enlarge):

Dr. Raghavan's publication titles indicate his primary work is care of Veterans
Word cloud from pub titles
Dr. Raghavan's collaborations are primarily from the University of Colorado
Research collaboration map
The following research fields have been used to summarize Dr. Raghavan's publications and grants. The categories are based on 67 publications and 2 grants.
Publications Grants
Diabetes Cardiovascular
Clinical Research Diabetes
Prevention Heart Disease
Cardiovascular Clinical Research
Heart Disease Prevention
Genetics Atherosclerosis
Nutrition Nutrition
Human Genome Heart Disease - Coronary Heart Disease
Obesity Clinical Trials and Supportive Activities
Heart Disease - Coronary Heart Disease  

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Recent Publications

 

2022

 

Tcheandjieu C, Zhu X, Hilliard AT, Clarke SL, Napolioni V, Ma S, Lee KM, Fang H, Chen F, Lu Y, Tsao NL, Raghavan S, Koyama S, Gorman BR, Vujkovic M, Klarin D, Levin MG, Sinnott-Armstrong N, Wojcik GL, Plomondon ME, Maddox TM, Waldo SW, Bick AG, Pyarajan S, Huang J, Song R, Ho YL, Buyske S, Kooperberg C, Haessler J, Loos RJF, Do R, Verbanck M, Chaudhary K, North KE, Avery CL, Graff M, Haiman CA, Le Marchand L, Wilkens LR, Bis JC, Leonard H, Shen B, Lange LA, Giri A, Dikilitas O, Kullo IJ, Stanaway IB, Jarvik GP, Gordon AS, Hebbring S, Namjou B, Kaufman KM, Ito K, Ishigaki K, Kamatani Y, Verma SS, Ritchie MD, Kember RL, Baras A, Lotta LA; Regeneron Genetics Center; CARDIoGRAMplusC4D Consortium; Biobank Japan; Million Veteran Program, Kathiresan S, Hauser ER, Miller DR, Lee JS, Saleheen D, Reaven PD, Cho K, Gaziano JM, Natarajan P, Huffman JE, Voight BF, Rader DJ, Chang KM, Lynch JA, Damrauer SM, Wilson PWF, Tang H, Sun YV, Tsao PS, O'Donnell CJ, Assimes TL. Large-scale genome-wide association study of coronary artery disease in genetically diverse populations. Nat Med. 2022 Aug 1. doi: 10.1038/s41591-022-01891-3. Epub ahead of print. PMID: 35915156

O'Sullivan JW, Raghavan S, Marquez-Luna C, Luzum JA, Damrauer SM, Ashley EA, O'Donnell CJ, Willer CJ, Natarajan P; American Heart Association Council on Genomic and Precision Medicine; Council on Clinical Cardiology; Council on Arteriosclerosis, Thrombosis and Vascular Biology; Council on Cardiovascular Radiology and Intervention; Council on Lifestyle and Cardiometabolic Health; and Council on Peripheral Vascular Disease. Polygenic Risk Scores for Cardiovascular Disease: A Scientific Statement From the American Heart Association. Circulation. 2022 Jul 18:101161CIR0000000000001077. doi: 10.1161/CIR.0000000000001077. Epub ahead of print. PMID: 35862132
Learn more about this publication at Dimensions

Josey KP, Yang F, Ghosh D, Raghavan S. A calibration approach to transportability and data-fusion with observational data. Stat Med. 2022 Jul 18. doi: 10.1002/sim.9523. Epub ahead of print. PMID: 35848098
Learn more about this publication at Dimensions

Raghavan S, Huang J, Tcheandjieu C, Huffman JE, Litkowski E, Liu C, Ho YA, Hunter-Zinck H, Zhao H, Marouli E, North KE; VA Million Veteran Program, Lange E, Lange LA, Voight BF, Gaziano JM, Pyarajan S, Hauser ER, Tsao PS, Wilson PWF, Chang KM, Cho K, O'Donnell CJ, Sun YV, Assimes TL. A multi-population phenome-wide association study of genetically-predicted height in the Million Veteran Program. PLoS Genet. 2022 Jun 2;18(6):e1010193. doi: 10.1371/journal.pgen.1010193. PMCID: PMC9162317. PMID: 35653334
Learn more about this publication at Dimensions

Edward JA, Josey K, Bahn G, Caplan L, Reusch JEB, Reaven P, Ghosh D, Raghavan S. Heterogeneous treatment effects of intensive glycemic control on major adverse cardiovascular events in the ACCORD and VADT trials: a machine-learning analysis. Cardiovasc Diabetol. 2022 Apr 27;21(1):58. doi: 10.1186/s12933-022-01496-7. PMID: 35477454
Learn more about this publication at Dimensions

Raghavan S, Warsavage T, Liu WG, Raffle K, Josey K, Saxon DR, Phillips LS, Caplan L, Reusch JEB. Trends in Timing of and Glycemia at Initiation of Second-line Type 2 Diabetes Treatment in U.S. Adults. Diabetes Care. 2022 Mar 28:dc212492. doi: 10.2337/dc21-2492. Epub ahead of print. PMID: 35344584
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Kim J, Jensen A, Ko S, Raghavan S, Phillips LS, Hung A, Sun Y, Zhou H, Reaven P, Zhou JJ. Systematic Heritability and Heritability Enrichment Analysis for Diabetes Complications in UK Biobank and ACCORD Studies. Diabetes. 2022 Feb 8:db210839. doi: 10.2337/db21-0839. Epub ahead of print. PMID: 35133398
Learn more about this publication at Dimensions

Lu B, Posner D, Vassy JL, Ho YL, Galloway A, Raghavan S, Honerlaw J, Tarko L, Russo J, Qazi S, Orkaby AR, Tanukonda V, Djousse L, Gaziano JM, Gagnon DR, Cho K, Wilson PWF. Prediction of Cardiovascular and All-Cause Mortality After Myocardial Infarction in US Veterans. Am J Cardiol. 2022 Jan 18:S0002-9149(21)01265-0. doi: 10.1016/j.amjcard.2021.12.036. Epub ahead of print. PMID: 35063273
Learn more about this publication at Dimensions

2021

 

Wu P, Moon JY, Daghlas I, Franco G, Porneala BC, Ahmadizar F, Richardson TG, Isaksen JL, Hindy G, Yao J, Sitlani CM, Raffield LM, Yanek LR, Feitosa MF, Cuadrat RRC, Qi Q, Arfan Ikram M, Ellervik C, Ericson U, Goodarzi MO, Brody JA, Lange L, Mercader JM, Vaidya D, An P, Schulze MB, Masana L, Ghanbari M, Olesen MS, Cai J, Guo X, Floyd JS, Jäger S, Province MA, Kalyani RR, Psaty BM, Orho-Melander M, Ridker PM, Kanters JK, Uitterlinden A, Davey Smith G, Gill D, Kaplan RC, Kavousi M, Raghavan S, Chasman DI, Rotter JI, Meigs JB, Florez JC, Dupuis J, Liu CT, Merino J. Obesity Partially Mediates the Diabetogenic Effect of Lowering LDL Cholesterol. Diabetes Care. 2021 Nov 17:dc211284. doi: 10.2337/dc21-1284. Epub ahead of print. PMID: 34789503

Raghavan S, Josey K, Bahn G, Reda D, Basu S, Berkowitz SA, Emanuele N, Reaven P, Ghosh D. Generalizability of heterogeneous treatment effects based on causal forests applied to two randomized clinical trials of intensive glycemic control. Ann Epidemiol. 2021 Jul 16:S1047-2797(21)00212-X. doi: 10.1016/j.annepidem.2021.07.003. Epub ahead of print. PMID: 34280545

Stanislawski MA, Litkowski E, Raghavan S, Harrall KK, Shaw J, Glueck DH, Lange EM, Dabelea D, Lange LA. Genetic Risk Score for Type 2 Diabetes and Traits Related to Glucose-Insulin Homeostasis in Youth: The Exploring Perinatal Outcomes Among Children (EPOCH) Study. Diabetes Care. 2021 Jul 13:dc210464. doi: 10.2337/dc21-0464. Epub ahead of print. PMID: 34257098

Stanislawski MA, Litkowski E, Fore R, Rifas-Shiman SL, Oken E, Hivert MF, Lange EM, Lange LA, Dabelea D, Raghavan S. Genetic Interactions with Intrauterine Diabetes Exposure in Relation to Obesity: The EPOCH and Project Viva Studies. Pediatr Rep. 2021 Jun 1;13(2):279-288. doi: 10.3390/pediatric13020036. PMID: 34205853

Josey KP, Berkowitz SA, Ghosh D, Raghavan S. Transporting experimental results with entropy balancing. Stat Med. 2021 May 20. doi: 10.1002/sim.9031. Epub ahead of print. PMID: 34018204

Kini V, Mosley B, Raghavan S, Khazanie P, Bradley SM, Magid DJ, Ho PM, Masoudi FA. Differences in High- and Low-Value Cardiovascular Testing by Health Insurance Provider. J Am Heart Assoc. 2021 Jan 28:e018877. doi: 10.1161/JAHA.120.018877. Epub ahead of print. PMID: 33506684

Raghavan S, Jablonski K, Delahanty LM, Maruthur NM, Leong A, Franks PW, Knowler WC, Florez JC, Dabelea D; Diabetes Prevention Program Research Group. Interaction of diabetes genetic risk and successful lifestyle modification in the Diabetes Prevention Program. Diabetes Obes Metab. 2021 Jan 4. doi: 10.1111/dom.14309. Epub ahead of print. PMID: 33394545

2020

 

Salahuddin T, Richardson V, McNeal DM, Henderson K, Hess PL, Raghavan S, Saxon DR, Valle JA, Waldo SW, Ho PM, Schwartz GG. Potential unrealized mortality benefit of glucagon-like peptide-1 receptor agonists and sodium-glucose co-transport-2 inhibitors: A report from the Veterans Health Administration Clinical Assessment, Reporting and Tracking program. Diabetes Obes Metab. 2021 Jan;23(1):97-105. doi: 10.1111/dom.14193. Epub 2020 Oct 3. PMID: 32902128

Raghavan S, Ho YL, Vassy JL, Posner D, Honerlaw J, Costa L, Phillips LS, Gagnon DR, Wilson PWF, Cho K. Optimizing Atherosclerotic Cardiovascular Disease Risk Estimation for Veterans With Diabetes Mellitus. Circ Cardiovasc Qual Outcomes. 2020 Aug 31:CIRCOUTCOMES120006528. doi: 10.1161/CIRCOUTCOMES.120.006528. Epub ahead of print. PMID: 32862698

Raghavan S, Liu WG, Berkowitz SA, Barón AE, Plomondon ME, Maddox TM, Reusch JEB, Ho PM, Caplan L. Association of Glycemic Control Trajectory with Short-Term Mortality in Diabetes Patients with High Cardiovascular Risk: a Joint Latent Class Modeling Study. J Gen Intern Med. 2020 Aug;35(8):2266-2273. doi: 10.1007/s11606-020-05848-5. Epub 2020 Apr 24. PMCID: PMC7403288. PMID: 32333313

Raghavan S, Xu K, Coffman CJ, Pabich S, Edelman D, Voils CI. Associations of Diabetes Genetic Risk Counseling with Incident Diabetes and Weight: 5-Year Follow-up of a Randomized Controlled Trial. J Gen Intern Med. 2020 Mar;35(3):944-946. doi: 10.1007/s11606-019-05126-z. Epub 2019 Jul 16. PMCID: PMC7080941. PMID: 31313118

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Grants & Funding

 

Machine Learning and Longitudinal Analyses of Metformin Response Among Veterans

NIH website: https://reporter.nih.gov/project-details/9929956

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Media (Presentations, webinars, podcasts, etc.

 

Podcast: What does height have to do with disease risk

On this episode of Health Findings in Focus our Investigator Dr. Sridharan Raghavan talks about his recent paper, “A multi-population phenome-wide association study of genetically-predicted height in the Million Veteran Program”. The paper draws on data from the VA Million Veteran Program, which is a national research program to learn how genes, lifestyle, and military exposures affect health and illness. Listen to learn how height might play a role in certain diseases and what this research means.
Learn more about the VA Million Veteran Program (MVP)

 

Human Medical Genetics and Genomics Presentation by Dr. Sridharan Raghavan

11 March 2021 - Dr. Sridharan Raghavan gave a presentation titled, "What clinical data linked to genetics can teach us about diabetes complications and height as a disease risk factor." Unfortunately, there is no recording to share.