COIN Investigators & Staff
COIN Investigators
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Charles C. Engel, MD, MPH
- Title: Core Investigator; Co-Director VA Advanced Fellowship Program in HSR
Professor of Psychiatry and Behavioral Sciences, University of Washington School of Medicine - Contact: Charles.Engel@va.gov
- Location: Seattle
- See Dr. Engel's Dimensions profile that includes: publications, grants, datasets, patents and clinical trials
Charles Engel, MD, MPH is Core VA HSR Investigator in the Seattle Center for Innovation, Codirector of the Center's Advanced Research Fellowship on Learning Health Systems, Professor in the Department of Psychiatry and Behavioral Sciences at the University of Washington School of Medicine, and Adjunct Physician Policy Researcher at the RAND Corporation. A retired Army Colonel and combat veteran, Engel's work has focused on trauma-informed health systems and strategies for improving the quality of primary care for chronic mental and physical health conditions following war and other occupationally related exposures. Health conditions of research interest have included polytraumatic injuries and occupational trauma syndromes ranging from blast injury, mild traumatic brain injury, chronic pain and fatigue, Gulf War syndrome, military sexual trauma, PTSD and depression.
Engel is an experienced, mixed qualitative and quantitative research methodologist, having led a number of large pragmatic randomized trials, program evaluations, and implementation science studies. He has authored or coauthored nearly 200 scholarly papers, including in the New England Journal of Medicine, JAMA, and the American Journal of Psychiatry. Funding for his work has come from the National Institutes of Health, Centers for Disease Control, Department of Veterans Affairs, Department of Defense and other organizations. Before joining UW Psychiatry and the AIMS Center in 2021, Dr. Engel was Senior Physician Policy Researcher at the RAND Corporation from 2013 to 2020 and Associate Chair (Research) at Uniformed Services University's Department of Psychiatry from 2001-2013. Engel has served on the board of directors of the International Society for Traumatic Stress Studies, has testified twice before Congress, received a number of awards, and delivered invited lectures in over 10 countries. He received both his MD and MPH from the University of Washington School of Medicine.
Grants
California Statewide ACEs Learning Collaborative: A Data Hub Supporting the Implementation of Screening for Childhood Trauma
Role: Co-PI
This project evaluates the implementation of a State Surgeon General mandated screening for childhood trauma (ACEs) in children and adults receiving Medi-Cal system primary care. Qualitative research assesses potential adverse effects of screening from the perspective of patients/parents and the intended and unintended effects of program implementation from the perspective of participating practices. A quantitative data hub for ongoing implementation evaluation will be assessed for feasibility and potential development.
Funder: State of California Department of Health Care Services and University of California, San Francisco
Tenth Department of Defense Blast Injury Research State-of-the-Science Meeting: Developing DoD Research Priorities and Strategies
Role: Co-PI
This project is a mixed method (literature review, scientific meeting, consensus committee) evaluation of the DoD research portfolio pertaining to a topic in blast-related injury. The primary goal is to develop objective, independent recommendations for DoD research and research policy priorities relating to an important topic in Blast Injury Research. The central topic is currently under consideration.
Funder: Office of the Secretary of Defense, Defense Health Agency
Comparative Effectiveness PTSD Trial of Sequenced Pharmacotherapy and Psychotherapy in Primary Care
Role: Co-PI
This is a large, multisite randomized pragmatic clinical trial, to be completed in two large US comparing the effectiveness of primary care PTSD treatment sequencing strategies involving Written Exposure Therapy and commonly used selective serotonin reuptake inhibitors (SSRIs) and a serotonin-norepinephrine reuptake inhibitor (SNRI).
Funder: Patient Centered Outcomes Research Institute (PCORI)
Ninth Blast Related Injury State-of-the-Science Research Portfolio Evaluation
Role: PI
This project was a mixed method (literature review, scientific meeting, consensus committee) evaluation of the DoD research portfolio pertaining to a topic in blast-related injury. The stakeholder selected topic was "Mitigating the Impact of Blast-related Burn Injuries: From Prolonged Field Care to Rehabilitation and Resilience".
Funder: Office of the Secretary of Defense
Evaluating the Quality and Safety of Pain Care and Opioid Prescribing in the Military Health System
Role: Co-I
This project is an evaluation of the US Military Health System’s pain care and opioid prescribing using automated health system data sources.
Funder: Office of the Assistant Secretary of Defense for Health Affairs
DoD-Wide Assessment of Blast Related Brain Health Research Portfolio Evaluation
Role: PI
This project is a mixed methods evaluation of the DoD blast-related research portfolio pertaining to traumatic brain injury and psychological health from 2007-2018.
Funder: Office of the Secretary of Defense
Confidentiality of Military Mental Health Services: Comparison of Military and Civilian Standards and Perceptions of Military Stakeholders
Role: Co-PI
This project is a mixed methods evaluation of DoD mental health care confidentiality standards.
Funder: Office of the Secretary of Defense
2018 Department of Defense Health-Related Behaviors Survey of Active and Reserve Component Personnel
Role: Co-PI
This project is a large population-based survey of behavioral health and health-related behaviors among a representative sample of active and reserve component U.S. military personnel from all branches of service, the Marine Corps, and Coast Guard.
Funder: Office of the Secretary of Defense
Development of a Knowledge Readiness Level Framework for Medical Research
Role: Co-PI
This project involved the development and early testing of a translational research framework for quantitative prediction of future population impact of health research.
Funder: Office of the Secretary of Defense
Post Admission Cognitive Therapy (PACT) for the Inpatient Treatment of Military Personnel with Suicidal Behaviors
Role: Co-PI
This project is a multisite randomized trial of a cognitive therapy (versus usual care) intervention for suicidal military health system beneficiaries (including active duty military) hospitalized at two large military medical center inpatient psychiatric facilities. Follow-up is for 12 months with primary outcomes being time to recurrent suicide attempt and number of future suicide attempts.
Funder: Military Occupational Medicine Research Program Award
Randomized Effectiveness Trial of a Systems-Level Approach to Stepped Care for War-Related PTSD
Role: PI
This project was a 6-site randomized controlled trial of a collaborative care intervention for service members with PTSD and depression seeking primary care in the military health system. The study compared the model to usual care over one year with research assessments at baseline and 3-, 6-, and 12-month follow-up. Other studies that were part of the project involved (1) qualitative research to assess the acceptability of the care delivery model for primary care providers and patients and (2) cost-effectiveness analysis.
Funder: Clinical Trial Award Department of Defense Deployment-Related Medical Research Program
Recent Publications
2024
Reed DE 2nd, Engel CC, Coggeshall S, Michel M, Etingen B, Bolton RE, Kroenke K, Bokhour BG, Zeliadt SB. Is the PHQ-2 a Good Measure to Inform Providers About Patient Well-Being and Functioning? Data From the Veterans Health and Life Survey. Med Care. 2024 Dec 1;62(12 Suppl 1):S76-S83. doi: 10.1097/MLR.0000000000002069. Epub 2024 Nov 11. PMCID: PMC11548814.
PMID: 39514499.
Reed DE 2nd, Palitsky R, Engel CC, Williams RM, Kroenke K, Bokhour BG, Zeliadt SB. Progress Toward Meaning-as-Goal and Its Association with Pain, Functioning, and Global Meaning and Purpose Among Veterans with Co-occurring Chronic Pain and PTSD. Int J Behav Med. 2024 Sep 12. doi: 10.1007/s12529-024-10320-3. Epub ahead of print.
PMID: 39266910.
Fortney JC, Kaysen DL, Engel CC, Cerimele JM, Nolan JP Jr, Chase E, Blanchard BE, Hauge S, Bechtel J, Moore DL, Taylor A, Acierno R, Nagel N, Sripada RK, Painter JT, DeBeer BB, Bluett E, Teo AR, Morland LA, Heagerty PJ. Sequenced treatment effectiveness for posttraumatic stress (STEPS) trial: A protocol for a pragmatic comparative effectiveness trial with baseline results. Contemp Clin Trials. 2024 Jun 10:107606. doi: 10.1016/j.cct.2024.107606. Epub ahead of print.
PMID: 38866094
Learn more about this publication on Dimensions
2023
Hepner KA, Sousa JL, Roth CP, Huilgol SS, Jean C, Schulson LB, Gandhi P, Malika N, Engel CC. Improving Pain Care for Service Members: Administrator, Provider, and Patient Perspectives on Treatment, Policies, and Opportunities for Change. Rand Health Q. 2023 Dec 20;11(1):3. PMCID: PMC10732241.
PMID: 38264313
Reed DE, Engel CC, DeFaccio R, Gaj L, Douglas JH, Williams RM, Etingen B, Kroenke K, Bokhour BG, Zeliadt SB. Examining the Veterans Health Administration whole health model of care within the context of posttraumatic stress disorder. Psychol Serv. 2023 Dec 11. doi: 10.1037/ser0000822. Epub ahead of print.
PMID: 38079475
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Reed DE, Williams RM, Engel CC, Zeliadt SB. Introducing the integrated model of co-occurring chronic pain and posttraumatic stress disorder: Adding meaning-making and existential concepts to current theory. Psychol Trauma. 2023 Oct 19. doi: 10.1037/tra0001591. Epub ahead of print.
PMID: 37856393
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Dunbar MS, Breslau J, Collins R, Beckman R, Engel CC. Heterogeneity in Unmet Treatment Need and Barriers to Accessing Mental Health Services Among U.S. Military Service Members with Serious Psychological Distress. Adm Policy Ment Health. 2023 Aug 18. doi: 10.1007/s10488-023-01289-4. Epub ahead of print.
PMID: 37596460
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Reed DE, Chen C, Harvey K, Engel CC, Kroenke K, Defaccio R, Coggeshall S, Taylor SL, Bokhour BG, Zeliadt SB. Utilization of Whole Health and Longitudinal Outcomes After Screening Positive for Possible Depression Documented in Veterans Health Administration's Electronic Health Record. J Integr Complement Med. 2023 Apr 11. doi: 10.1089/jicm.2022.0772. Epub ahead of print.
PMID: 37040272
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2022
Hepner KA, Roth CP, Sherry TB, McBain RK, Ruder T, Engel CC. Assessing the Quality of Outpatient Pain Care and Opioid Prescribing in the Military Health System. Rand Health Q. 2022 Aug 31;9(4):19. PMCID: PMC9519116. PMID: 36238003.
Tomoaia-Cotisel A, Eberhart NK, Engel CC, Mendel P, Alvarado G, Qureshi N, Allen SD. A Process Evaluation of Primary Care Behavioral Health Integration in the Military Health System. Rand Health Q. 2022 Jun 30;9(3):15. PMCID: PMC9242578. PMID: 35837508.
Meyer EG, DeSilva RB, Hann MC, Aggarwal NK, Brim WL, Engel CC, Lu FG, Lewis-Fernández R. Adapting the Cultural Formulation Interview for the Military. Psychiatr Serv. 2022 Feb 23:appips202100523. doi: 10.1176/appi.ps.202100523. Epub ahead of print. PMID: 35193377.
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Reed DE 2nd, Bokhour BG, Gaj L, Barker AM, Douglas JH, DeFaccio R, Williams RM, Engel CC, Zeliadt SB. Whole Health Use and Interest Across Veterans With Co-Occurring Chronic Pain and PTSD: An Examination of the 18 VA Medical Center Flagship Sites. Glob Adv Health Med. 2022 Feb 11;11:21649561211065374. doi: 10.1177/21649561211065374. PMCID: PMC8841911. PMID: 35174004. Learn more about this publication on Dimensions
2021
Littman AJ, Bratman GN, Lehavot K, Engel CC, Fortney JC, Peterson A, Jones A, Klassen C, Brandon J, Frumkin H. Nature versus urban hiking for Veterans with post-traumatic stress disorder: a pilot randomised trial conducted in the Pacific Northwest USA. BMJ Open. 2021 Sep 23;11(9):e051885. doi: 10.1136/bmjopen-2021-051885. PMID: 34556516
Dunbar MS, Schuler MS, Meadows SO, Engel CC. Associations Between Mental and Physical Health Conditions and Occupational Impairments in the U.S. Military. Mil Med. 2021 Feb 3:usab021. doi: 10.1093/milmed/usab021. Epub ahead of print. PMID: 33533897
2020
Malâtre-Lansac A, Engel CC, Xenakis L, Carlasare L, Blake K, Vargo C, Botts C, Chen PG, Friedberg MW. Factors Influencing Physician Practices' Adoption of Behavioral Health Integration in the United States: A Qualitative Study. Ann Intern Med. 2020 Jul 21;173(2):92-99. doi: 10.7326/M20-0132. Epub 2020 Jun 2. PMID: 32479169
2019
Novak LA, Belsher BE, Freed MC, McCutchan PK, Liu X, Evatt DP, Tanielian T, Bray RM, Engel CC. Impact of financial reimbursement on retention rates in military clinical trial research: A natural experiment within a multi-site randomized effectiveness trial with active duty service members. Contemp Clin Trials Commun. 2019 Apr 13;15:100353. doi: 10.1016/j.conctc.2019.100353. PMCID: PMC6477623. PMID: 31032460
